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Isoptin

Generic Isoptin (Verapamil)

Isoptin is a calcium channel blocker, it treats high blood pressure relaxing and widening blood vessels.
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40mg
60pills
Isoptin $113.00
$93.99
$1.57 per pill
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40mg
90pills
Isoptin $154.00
$127.99
$1.42 per pill
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120mg
30pills
Isoptin $52.00
$42.99
$1.43 per pill
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120mg
60pills
Isoptin $82.00
$67.99
$1.13 per pill
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120mg
90pills
Isoptin $110.00
$91.99
$1.02 per pill
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save: $36.90
240mg
30pills
Isoptin $62.00
$51.99
$1.73 per pill
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240mg
60pills
Isoptin $100.00
$82.99
$1.38 per pill
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save: $21.00
240mg
90pills
Isoptin $136.00
$112.99
$1.26 per pill
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save: $42.30
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Common use

Isoptin is a Ca2+-channel blocker which relaxes (widens) veins and arteries, which makes it easier for the heart to pump and this way Isoptin reduces its workload. Calcium triggers contraction of smooth muscles and when its entrance to the myocytes, it results in relaxation of the arterial muscles, improved oxygen delivery to the myocardial tissue, and decreased total peripheral resistance, systemic blood pressure, and after-load. Isoptin also decreases the conduction of electrical impulses through the heart that control the coordination of contraction, this slows the rate of contraction. Isoptin is used to treat hypertension, to treat angina, control some types of irregular heartbeats.



Dosage and direction

Take orally with or without food. Daily dose is 180-480 mg which may be taken as a single dose or divided in two or three intakes. Take exactly as prescribed by your doctor, never exceed the dose recommended to you.



Precautions

Avoid drinking alcoholic beverages, grapefruit juice or eating grapefruit. Alcohol is able worsen side effects of Isoptin (drowsiness and dizziness) while grapefruit interacts with components of the drug. Do not get up too fast from a sitting or lying position as you may feel dizzy.



Contraindications

Isoptin is contraindicated in patients with hypersensitivity to components of the medication, severe left ventricular dysfunction, hypotension (systolic pressure less than 90 mm Hg) or cardiogenic shock, sick sinus syndrome (except in patients with a functioning artificial ventricular pacemaker), atrioventricular block degree II-III (except in patients with a functioning artificial ventricular pacemaker), atrial flutter or atrial fibrillation and an accessory bypass tract (Wolff-Parkinson-White, Lown-Ganong-Levine syndromes).



Side effects

Arpamyl is usually well tolerated. Most common side effects include dizziness, weakness or fainting, swelling of the lower extremities, rash, headache, and constipation. Jaundice, swelling, difficulty breathing, rashes are also possible. If you experience severe side effects listed above seek for immediate medical attention.



Drug interaction

Isoptin inhibits elimination of alcohol, increases the efficacy of doxorubicin both in tissue culture systems and in patients. Cyclophosphamide, oncovin, procarbazine, prednisone (COPP) and the vindesine, adriamycin, cisplatin (VAC) cytotoxic drug regimens are able to decrease absorption of Isoptin. Co-administration of Isoptin with aspiring in rare cases increases risk of bleeding. Correction of digoxin dosage is important in patients treated with Isoptin. Chronic verapamil treatment can increase serum digoxin levels by 50% to 75% during the first week of therapy leading to digitalis toxicity. Co-administration with oral antihypertensive agents results in additive effects. Inform your doctor about all medications you take, especially about Disopyramide, Flecainide, Quinidine, Phenobarbital, Cyclosporin, medications which contain lithium. This medication may change results of certain liver tests to mildly abnormal.



Missed dose

Take the dose you forgot as soon as you remember. If it is almost time for your next intake just skip the next dose and return to your regular schedule.



Overdose

If you experience slow heartbeat and fainting, they may be symptoms of overdose. Seek for immediate medical attention if you suppose that too much of Isoptin was taken.



Storage

Store at room temperature 15-30 C (59-86 F) away from light, moisture, pets and children.



Disclaimer

We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.

Metformin

Other names used:

  • Glucophage®

Active Ingredients:

  • Metformin Hydrochloride

The commercial name of the medication may differ from the brand one. Generic Metformin manufactured by Mankind Pharma is available under commercial name Metname.

How does Metformin work and what pharmaceutical group does it belong to?

Metformin is an hypoglycemic drug that belongs to a group of biguanidines. It works by decreasing the concentration of glucose in the blood through inhibition of gluconeogeneisis in the liver, decreasing the absorption of glucose from the GI tract and the utilization of glucose in the tissues. If Insulin is absent in the blood then metformin does not exert any effects. The drug stabilizes and decreases body weight.

Which conditions are treated with Metformin?

The preparation is indicated in treatment of Diabetes mellitus type II. Especially in cases which are accompanied by obesity.

What should a patient know before using Metformin?

The Metformin should not be used in cases of:

  • Hypersensitivity to any components of the preparation
  • Hyperglycemic coma
  • Ketoacidosis
  • Chronic liver failure
  • Acute myocardial infraction
  • Respiratory disorder
  • Dehydration
  • Infectious disease of different origin
  • Surgery
  • Pregnancy
  • Lactation period
  • Low calorie diet

The preparation should be used with caution in:

  • Elderly patients older then 60 years
  • Patients performing difficult physical activity

Which adverse effects may manifest when using the medication?

The side effects of Metformin include:

  • Gastrointestinal tract: nausea, vomiting, metallic taste, decreased appetite, dyspepsiam meteorism, abdominal pain
  • Metabolism: lactic acidosis, avitaminosis B12
  • Haemopoietic organs: megablast anemia
  • Allergic reactions: skin rash

It is not necessary that the side effects will manifest in an individual but the possibility still exist. For more information please consult your health care provider.

Which groups of drugs or specific preparations may interact with Metformin?

The drug is affected by the following:

  • Ethanol
  • Anticoagulants
  • H2-histamine receptor blockers
  • MAO inhibitors
  • Other diabetes treatments
  • Antibiotics
  • ACE inhibitors
  • Increased cholesterol treatment
  • Oral contraceptives
  • Corticosteroids
  • Adrenomimetics
  • Thyroid gland hormones
  • Diuretics
  • NSAID's
  • Narcotic analgesics
  • Antivirals
  • Neuroleptics

Tell your doctor about all the herbal preparations as well as prescription drugs that you are currently taking even if they are not on the list.

Important information for the patient:

Metformin is supplied for individual use. Do not use it to treat other conditions not listed in the leaflet. Keep the product out of children reach. Do not reuse any disposable materials if supplied with the preparation.